A New Approach for an Organocatalytic Multicomponent Domino Asymmetric Reaction

摘要

The field of asymmetric catalysis has recently been complemented with organocatalysis - a rapidly expanding and new important field in organic chemistry.[1] A central role in organocatalysis is played by chiral secondary amines which can activate carbonyl compounds, either by enamine or iminium intermediates.[1]-[3] These types of activation have been exploited to functionalize aldehydes and ketones with electrophiles and ,-unsaturated compounds with nucleophiles.