Thiamine Biosynthesis in Escherichia coli:Identification of the Intermediate and By-Product Derived from Tyrosine

摘要

Thiamine is an essential cof actor in many metabolic pathways and is required by all living organisms.The biosynthesis of thiamine phosphate is convergent,linking two independently biosynthesized heterocyclic precursors (Scheme 1,6 and 7) in the final step.