Two-Component Liquid Crystals as Chiral Reaction Media: Highly Enantioselective Photodimerization of an Anthracene Derivative Driven by the Ordered Microenvironment

摘要

Inspired by natural systems like enzymes, chemists have long sought tailored microenvironments that can drive targeted chemical transformations in a highly selective manner. For this aim, a number of constrained reaction fields have been explored to date, including crystals coordination polymers,zeolites, clays, and discrete hosts in homogeneous solutions. Among these classes of reaction fields, crystals are regarded as one of the most successful classes, in which reactive molecules are aligned in a highly defined manner with infinite periodicity. In particular, crystalline-state reaction fields can provide the ultimate environment for intra- and intermolecular photochemical reactions, leading to near-perfect regio- and stereocontrol, and providing access to realms unexplored in traditional chemistry using homogeneous media.