Kinetics of Iminium Ion Catalysis

摘要

Since MacMillan's original report in 2000,[1a] iminium ion catalysis using cyclic secondary amines has been established as an effective platform for asymmetric Diels-Alder,[1] conjugate addition,[2]-[6] [3+2] cycloaddition,[7] [4+3] cycloaddition,[8] and conjugate reduction[9] reactions, thereby providing powerful new methods for fundamental bond-construction processes. Such reactions frequently proceed in high yield and with exceptional levels of asymmetric induction, thus forming a new mode of reactivity that has met with overwhelming acceptance from the chemical community owing to the highly practical nature of the transformations.