A Concise Synthesis of Eupomatilones 4,6,and 7 by Rhodium-Catalyzed Enantioselective Desymmetrization of Cyclic meso Anhydrides with Organozinc Reagents Generated In Situ

摘要

Cross-coupling methodology,as a subset of transition-metal-catalyzed reactions,has revolutionized the means by which complex molecules are constructed.Despite recent advances,significant challenges remain in this area,including the selective construction and definition of stereocenters.Although numerous activated acyl species have been utilized in the formation of ketones,carboxylic acid anhydrides have only recently been investigated as acylating agents in metal-mediated reactions.