Dual Catalysis:A Combined Enantioselective Bronsted Acid and Metal-Catalyzed Reaction-Metal Catalysis with Chiral Counterions

摘要

Radicicol A (F87-25 09.04,1,Scheme 1) belongs to the family of resorcylic acid lactones (RAL) and was first reported by researchers from Sandoz who identified this fungal metabolite from a screen for IL1 beta inhibition.While it was observed that 1 accelerated the degradation of specific mRNA sequences including those of IL1 beta,its precise molecular target was not identified.