Complex α-Pyrones Synthesized by a Gold-Catalyzed Coupling Reaction

摘要

We have been exploring a strategy for the synthesis of small molecules with properties that increase the probability of success in all facets of probe- and drug-discovery pipelines, including discovery, optimization, and manufacturing.[1] This strategy involves 1) the synthesis of building blocks with functionality suitable for subsequent coupling and pairing steps, 2) intermolecular coupling reactions that join the building blocks in all stereochemical combinations, and 3) intramolecular pairing reactions that join different combinations of functional groups to yield diverse skeletons.[2] Herein, we describe a multicomponent coupling reaction that we believe is well-suited for the coupling phase of this strategy, as it yields, among other substances, complex and diverse -pyrones, which are core elements found in many biologically active compounds.