Titanium-Catalyzed Asymmetric Epoxidation of Non-Activated Olefins with Hydrogen Peroxide

摘要

Asymmetric epoxidation of olefins is a potent method for synthesizing enantioenriched epoxides that are high-utility intermediates.Thus,over the past few decades,extensive research efforts have been devoted to the development of catalytic asymmetric epoxidation,and some excellent transition-metal catalysts based on titanium,manganese,vanadium,and molybdenum as well as organocatalysts such as chiral ketones have been reported.