Intracellular Hydrogelation of Small Molecules Inhibits Bacterial Growth

摘要

Self-assembly,a fundamental process on all scales,not only plays a vital role in nature but also offers a powerful strategy for constructing biomaterials.For example,rationally designed oligopeptide amphiphiles spontaneously form nano-fibers which gel biological fluids,potentially leading to a new class of biomaterials with applications in regenerative medicine.Similarly,hydrogels of small organic molecules,the result of hierarchical molecular self-assembly in an aqueous environment,are finding applications in tissue engineering,drug delivery,wound healing,and semiwet protein arrays.