A Novel Strategy towards the Total Synthesis of Cyclopeptide Alkaloids

摘要

Since the first structural determination of pandamine (1) by Goutarel and Pai's in 1963, the family of cyclopeptide alkaloids has grown rapidly and now encompasses over 200 compounds. These 13-, 14-, and 15-membered macrocycjes typically contain a para- or metacyclophane unit with a characteristic aryl-alkyl ether linkage. The widespread occurence of these compounds in nature makes them an important class of natural products. However, little is known about their biological and pharmacological properties due to their limited availability, The development of a practical synthetic method is therefore of utmost importance.