High Thermal Stability Imparted by a Designed Tandem Arg-Trp Stretch in an a-Helical Coiled Coil

摘要

Studies on de novo designed proteins involve the construction of unique tertiary structures and the creation of novel functions.Protein structures are mainly formed by various interactions,such as ion-pair,hydrogen-bonding,and hydro-phobic interactions.Recently,the cation-pi interaction was noted as one of the effective interactions judging from various protein structures in the PDB (protein data bank) databases,and it is thought to contribute to protein structure stabilization and protein-ligand interactions.