Stereocontrolled Solid-Phase Synthesis of a 90-Membered Library of Indoline-Alkaloid-like Polycycles from an Enantioenriched Aminoindoline Scaffold

摘要

With growing interest in the use of small molecules for dissecting protein-protein interactions and for understanding signaling pathways,the need for developing combinatorial methods to obtain small molecules that have stereochemical and skeletal diversity has also grown.Owing to their structural complexity and the diversity of their functional groups,natural products are a source of bioactive lead compounds,and it is highly likely that libraries of small molecules that also display these features would serve as valuable tools.