Structure and Unique Interactions with DNA of a Cationic Trans-Platinum Complex with the Nonplanar Bicyclic Piperidinopiperidine Ligand

摘要

The ability of square-planar platinum(II) complexes to covalently bind to cellular DNA and distort its structure has had an overwhelming impact on the lives of many cancer patients worldwide.The anticancer drug cisplatin (Figure 1 a),exerts its cytotoxic effect by binding covalently to two adjacent guanine residues on the same DNA strand (1,2-GpG cross-link),and the ensuing distortion of the DNA,triggers cellular processes that lead to the death of the cancer cell.