Genetically Selected Cyclic-Peptide Inhibitors of AICAR Transformylase Homodimerization

摘要

The de novo purine biosynthetic pathway is used by virtually all organisms for the production of purine nucleotides.The final two steps of this pathway(Scheme 1)are catalyzed by aminoimidazole-4-carboxamide ribonucleotide transformyl-ase/inosine monophosphate cyclohydrolase(AICAR Tfase/IMPCH),the two activities of a highly conserved 64 kDa bifunctional protein(ATIC)that possesses two distinct"domains.