Carbon -Carbon Bond Cleavage with Inversion of Configuration: Conversion of (R)-(+ )-l-Methoxytetrafluoropropio.nic Acid to (SH-) 1,2.2,2-Tetrafluoroethyl Methyl Ether

摘要

Asymmetric synthesis of Pharmaceuticals is of increasing interest, because in many cases only one enantiomer of a chiral drug may be effective. In the field of inhalational anesthetics differences in ihe pharmacological profiles of enantiomers have been noted. However, access to these small, highly fluorinated compounds in optically active form has been linked owmu to the scarcity of suitable synthetic methods. Enantiomeric sepa-ration of some of these compounds on a preparative scale has only recently been accomplished.