Novel continuous microwave assisted flow synthesis of nanosized manganese substituted hydroxyapatite

摘要

In this paper, we reported a novel continuous microwave assisted flow synthesis (CMFS) of nanosized manganese substituted hydroxyapatite particles by using calcium nitrate and diammonium hydrogen phosphate precursor solutions in only 7 min retention time at pH 9. The identification of nanoproduct was made by using X-ray diffraction (XRD), Transmission electron microscopy (TEM), Scanning electron microscopy (SEM), Dynamic light scattering (DLS), Fourier Transform Infrared Spectroscopy (FTIR) and Raman spectroscopy. The results indicated that nanosized manganese substituted hydroxyapatite particles were synthesized successfully in a shorter time period. The degree of crystallinity of the nanoproduct decreased with increasing manganese contents from 0% to 4%. At such conditions, variations in particles' size and morphology from larger rod shaped particles (similar to 110 nm) to smaller semispherical form (similar to 75 nm) was observed. Thus the use of continuous microwave assisted flow synthesis procedure facilitated faster production of manganese substituted hydroxyapatite nanoparticles suitable for bone replacement applications.