Interleukin, tumor necrosis factor-alpha and C-reactive protein profiles in melancholic and non-melancholic depression: A systematic review

摘要

Objective: The current diagnostic criteria for major depressive disorder (MDD) do not allow prediction of prognosis and therapeutic response. A possible strategy to improve this situation is the identification of depression subtypes on the bases of biomarkers reflecting underlying pathological processes such as neuro-inflammation.