Impact of uneven sample morphology on mass resolving power in linear MALDI‐TOF mass spectrometry: A comprehensive theoretical investigation

Cai Yi‐Hong; Wang Yi‐Sheng

摘要

Abstract > This work discusses the correlation between the mass resolving power of matrix‐assisted laser desorption/ionization time‐of‐flight mass analyzers and extraction condition with an uneven sample morphology. Previous theoretical calculations show that the optimum extraction condition for flat samples involves an ideal ion source design and extraction delay. A general expression of spectral feature takes into account ion initial velocity, and extraction delay is derived in the current study. The new expression extends the comprehensive calculation to uneven sample surfaces and above 90% Maxell‐Boltzmann initial velocity distribution of ions to account for imperfect ionization condition. Calculation shows that the impact of uneven sample surface or initial spatial spread of ions is negligible when the extraction delay is away from the ideal value. When the extraction delay approaches the optimum value, the flight‐time topology shows a characteristic curve shape, and the time‐domain mass spectral feature broadens with an increase in initial spatial spread of ions. For protonated 2,5‐dihydroxybenzoic acid, the mass resolving power obtained from a sample of 3‐μm surface roughness is approximately 3.3 times lower than that of flat samples. For ions of <fi>m</fi> / <fi>z</fi> 3000 coexpanded with 2,5‐dihydroxybenzoic acid, the mass resolving power in the 3‐μm surface roughness case only reduces roughly 7%. Comprehensive calculations also show that the mass resolving power of lighter ions is more sensitive to the accuracy of the extraction delay than heavier ions. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> >这项工作探讨了矩阵辅助激光解吸/电离飞行时间分析仪的质量分辨率与具有不均匀样品形态的提取条件的相关性。以前的理论计算表明，平面样本的最佳提取条件涉及理想的离子源设计和提取延迟。光谱特征的一般表达考虑了考虑离子初始速度，并且推动了当前研究中的提取延迟。新表达将综合计算扩展到不均匀的样品表面和高于90％的Maxell-Boltzmann初始速度分布，以考虑不完美的电离条件。计算表明，当提取延迟远离理想值时，不同的样品表面或离子初始空间扩散的影响可忽略不计。当提取延迟接近最佳值时，飞行时间拓扑显示特征曲线形状，并且时域质谱特征随着离子的初始空间扩散而变宽。对于质子化的2,5-二羟基苯甲酸，从3μm表面粗糙度的样品获得的质量分辨率约为比平坦样品的样品约为3.3倍。对于<fi> m </ fi> / <fi> 3000的离子，用2,5-二羟基苯甲酸柔和，3μm表面粗糙度壳体中的质量分辨率仅减少约7％。综合计算还表明，较轻离子的质量分辨率对提取延迟的精度比较重离子更敏感。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34906/'>《Journal of mass spectrometry: JMS》</a> <b style="margin: 0 2px;">|</b><span>2018年第4期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cai Yi‐Hong&option=202" target="_blank" rel="nofollow">Cai Yi‐Hong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Yi‐Sheng&option=202" target="_blank" rel="nofollow">Wang Yi‐Sheng;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Genomics Research CenterAcademia Sinica128 Academia Road Section 2 Nankang District Taipei 115 Taiwan;</p> <p>Genomics Research CenterAcademia Sinica128 Academia Road Section 2 Nankang District Taipei 115 Taiwan;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=extraction delay&option=203" rel="nofollow">extraction delay;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=comprehensive calculation&option=203" rel="nofollow">comprehensive calculation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mass resolving power&option=203" rel="nofollow">mass resolving power;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=matrix‐assisted laser desorption ionization&option=203" rel="nofollow">matrix‐assisted laser desorption ionization;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=surface roughness&option=203" rel="nofollow">surface roughness;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=time‐of‐flight&option=203" rel="nofollow">time‐of‐flight;</a> </p> <div class="translation"> 机译：提取延迟;综合计算;质量分辨率;矩阵辅助激光解吸电离;表面粗糙度;飞行时间; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025633296.html">Impact of uneven sample morphology on mass resolving power in linear MALDI‐TOF mass spectrometry: A comprehensive theoretical investigation</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cai Yi‐Hong&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Cai Yi‐Hong,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Yi‐Sheng&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wang Yi‐Sheng </a> <a href="/journal-foreign-34906/" target="_blank" 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