Binding of Cu <sup xmlns='http://www.wiley.com/namespaces/wiley'>++ and Cu <sup xmlns='http://www.wiley.com/namespaces/wiley'>2+2+ with peptides: Peptides?=?oxytocin, Arg <sup xmlns='http://www.wiley.com/namespaces/wiley'>88 ‐vasopressin, bradykinin, angiotensin‐I, substance‐P, somatostatin, and neurotensin

Jayasekharan Thankan; Gupta Shyam L.; Dhiman Vikas

摘要

Abstract > The intrinsic binding ability of 7 natural peptides (oxytocin, arg 8 ‐vasopressin, bradykinin, angiotensin‐I, substance‐P, somatostatin, and neurotensin) with copper in 2 different oxidation states (Cu I/II ) derived from different Cu +/2+ precursor sources have been investigated for their charge‐dependent binding characteristics. The peptide‐Cu I/II complexes, [M???( <fi>n</fi> ‐1)H?+? <fi>nC</fi> u I ] and [M???(2 <fi>n</fi> ‐1)H?+? <fi>nC</fi> u II ], are prepared/generated by the reaction of peptides with CuI solution/Cu‐target and CuSO <sub>4</sub> solution and are analyzed by using matrix‐assisted laser desorption/ionization (MALDI) time‐of‐flight mass spectrometry. The MALDI mass spectra of both [M???( <fi>n</fi> ‐1)H?+? <fi>nC</fi> u I ] and [M???(2 <fi>n</fi> ‐1)H?+? <fi>nC</fi> u II ] complexes show no mass shift due to the loss of ─H atoms in the main chain ─NH of these peptides by Cu + and Cu 2+ deprotonation. The measured <fi>m</fi> / <fi>z</fi> value indicates the reduction of Cu I/II oxidation state into Cu 0 during MALDI processes. The number and relative abundance of Cu + bound to the peptides are greater compared with the Cu 2+ bound peptides. Oxytocin, arg 8 ‐vasopres </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> >内在7天然肽的结合能力（催产素，Arg 8-vasopentsin，Bradykinin，血管紧张素-1，物质-P，somatostatin和Neurotensin，2种不同的氧化态（Cu I /）已经研究了来自不同Cu + / 2 + / sup>前体源的II </ sup>），用于其依赖性结合特征。肽-Cu I / II / II / II / II / II络合物，[M -??（<fi> n </ fi> -1）h？+？ <fi> nc </ fi> u i </ sup>]和[m ???（2 <fi> n </ fi> -1）h？+？ <fi> nc </ fi> U II </ sup>]由肽与CuI溶液/ Cu-靶和Cuso <sub> 4 </ sub>溶液的反应制备/产生，并分析使用基质辅助激光解吸/电离（MALDI）飞行时间质谱法。 [m吗？（<fi> n </ fi> -1）h？+的maldi质谱<fi> nc </ fi> u i </ sup>]和[m ???（2 <fi> n </ fi> -1）h？+？ <fi> nc </ fi> u ii </ sup>]复合物由于─h原子的损失而显示出没有质量偏移──这些肽通过Cu + </ sup> n和Cu 2 + </ sup>去质子化。测量的<fi> m </ fi> / <fi> z </ fi>值表明在MALDI过程中将Cu I / II / II / sup>氧化状态还原为Cu 0 </ sup> 。与Cu 2 + / sup>结合的肽相比，与肽结合的Cu + / sup>的数量和相对丰度较大。催产素，Arg 8 </ sup> -vaspres </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34906/'>《Journal of mass spectrometry: JMS》</a> <b style="margin: 0 2px;">|</b><span>2018年第4期</span><b style="margin: 0 2px;">|</b><span>共18页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jayasekharan Thankan&option=202" target="_blank" rel="nofollow">Jayasekharan Thankan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gupta Shyam L.&option=202" target="_blank" rel="nofollow">Gupta Shyam L.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dhiman Vikas&option=202" target="_blank" rel="nofollow">Dhiman Vikas;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Atomic and Molecular Physics Division Physics GroupBhabha Atomic Research CentreTrombay Mumbai 400 085 India;</p> <p>Atomic and Molecular Physics Division Physics GroupBhabha Atomic Research CentreTrombay Mumbai 400 085 India;</p> <p>Atomic and Molecular Physics Division Physics GroupBhabha Atomic Research CentreTrombay Mumbai 400 085 India;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=copper&option=203" rel="nofollow">copper;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=intrinsic binding&option=203" rel="nofollow">intrinsic binding;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=MALDI‐TOFMS&option=203" rel="nofollow">MALDI‐TOFMS;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=oxidation states&option=203" rel="nofollow">oxidation states;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=peptides&option=203" rel="nofollow">peptides;</a> </p> <div class="translation"> 机译：铜;内在结合;maldi-tofms;氧化态;肽; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025633292.html">Binding of Cu <sup xmlns="http://www.wiley.com/namespaces/wiley">++ and Cu <sup xmlns="http://www.wiley.com/namespaces/wiley">2+2+ with peptides: Peptides?=?oxytocin, Arg <sup xmlns="http://www.wiley.com/namespaces/wiley">88 ‐vasopressin, bradykinin, angiotensin‐I, substance‐P, somatostatin, and neurotensin</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jayasekharan Thankan&option=202" 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Binding of Cu ++ and Cu 2+2+ with peptides: Peptides?=?oxytocin, Arg 88 ‐vasopressin, bradykinin, angiotensin‐I, substance‐P, somatostatin, and neurotensin

摘要

Binding of Cu ^{++ and Cu ^{2+2+ with peptides: Peptides?=?oxytocin, Arg ^{88 ‐vasopressin, bradykinin, angiotensin‐I, substance‐P, somatostatin, and neurotensin}}}