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首页> 外文期刊>Journal of mass spectrometry: JMS >Mass spectrometry imaging of triglycerides in biological tissues by laser desorption ionization from silicon nanopost arrays
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Mass spectrometry imaging of triglycerides in biological tissues by laser desorption ionization from silicon nanopost arrays

机译：来自硅纳米孔阵列的激光解吸电离的生物组织中甘油三酯的质谱成像

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Abstract > Mass spectrometry imaging (MSI) is used increasingly to simultaneously detect a broad range of biomolecules while mapping their spatial distributions within biological tissue sections. Matrix‐assisted laser desorption ionization (MALDI) is recognized as the method‐of‐choice for MSI applications due in part to its broad molecular coverage. In spite of the remarkable advantages offered by MALDI, imaging of neutral lipids, such as triglycerides (TGs), from tissue has remained a significant challenge due to ion suppression of TGs by phospholipids, e.g. phosphatidylcholines (PCs). To help overcome this limitation, silicon nanopost array (NAPA) substrates were introduced to selectively ionize TGs from biological tissue sections. This matrix‐free laser desorption ionization (LDI) platform was previously shown to provide enhanced ionization of certain lipid classes, such as hexosylceramides (HexCers) and phosphatidylethanolamines (PEs) from mouse brain tissue. In this work, we present NAPA as an MSI platform offering enhanced ionization efficiency for TGs from biological tissues relative to MALDI, allowing it to serve as a complement to MALDI‐MSI. Analysis of a standard lipid mixture containing PC(18:1/18:1) and TG(16:0/16:0/16:0) by LDI from NAPA provided an ~49 and ~227‐fold higher signal for TG(16:0/16:0/16:0) relative to MALDI, when analyzed without and with the addition of a sodium acetate, respectively. In contrast, MALDI provided an ~757 and ~295‐fold higher signal for PC(18:1/18:1) compared with NAPA, without and with additional Na + . Averaged signal intensities for TGs from MSI of mouse lung and human skin tissues exhibited an ~105 and ~49‐fold increase, respectively, with LDI from NAPA compared with MALDI. With respect to PCs, MALDI provided an ~2 and ~19‐fold increase in signal intensity for mouse lung and human skin tissues, respectively, when compared with NAPA. The complementary coverage obtained by the two platforms demonstrates the utility of using both techniques to maximize the information obtained from lipid MS or MSI experiments. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 使用质谱成像（MSI）越来越多地用于同时检测广泛的生物分子，同时在生物组织部分内绘制它们的空间分布。基质辅助激光解吸电离（MALDI）被认为是MSI应用的选择方法，其由于其广泛的分子覆盖。尽管MALDI提供了显着的优势，但由于磷脂的离子抑制，来自组织的中性脂质的成像（例如甘油三酯（TGS））仍然是显着的挑战，例如磷脂。磷脂酰胆碱（PC）。为了帮助克服这种限制，引入硅纳米滤器阵列（NAPA）衬底以选择性地从生物组织切片中电离TGS。此前示出了该基质激光解吸电离（LDI）平台，以提供来自小鼠脑组织的六糖胺（己酸）和磷脂酰乙醇胺（PES）的某些脂质类别的增强电离。在这项工作中，我们将Napa作为MSI平台，为来自生物组织相对于MALDI的TGS提供增强的电离效率，使其能够作为MALDI-MSI的补充。通过NAPA的LDI分析含有PC（18：1/18：1）和TG（16：0/16：0/16：0）的TG的脂质混合物提供了〜49和〜227倍的TG信号（ 16：0/16：0/16：0）相对于MALDI，分别在没有添加乙酸钠的情况下分析。相比之下，与纳帕，没有额外的NA + </ sup> 。与马尔迪相比，来自小鼠肺和人体皮肤组织的MSI的TGS的平均信号强度分别显示出〜105〜49倍，LDI与NAPA相比。关于PC，MALDI分别与NAPA相比，MALDI分别为小鼠肺和人体皮肤组织的信号强度提供了〜2〜19倍。由两个平台获得的互补覆盖率证明了使用两种技术最大化从脂质MS或MSI实验获得的信息的效用。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34906/'>《Journal of mass spectrometry: JMS》</a> <b style="margin: 0 2px;">|</b><span>2020年第4期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fincher Jarod A.&option=202" target="_blank" rel="nofollow">Fincher Jarod A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Korte Andrew R.&option=202" target="_blank" rel="nofollow">Korte Andrew R.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dyer Jacqueline E.&option=202" target="_blank" rel="nofollow">Dyer Jacqueline E.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yadavilli Sridevi&option=202" target="_blank" rel="nofollow">Yadavilli Sridevi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Morris Nicholas J.&option=202" target="_blank" rel="nofollow">Morris Nicholas J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jones Derek R.&option=202" target="_blank" rel="nofollow">Jones Derek R.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shanmugam Victoria K.&option=202" target="_blank" rel="nofollow">Shanmugam Victoria K.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pirlo Russel K.&option=202" target="_blank" rel="nofollow">Pirlo Russel K.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vertes Akos&option=202" target="_blank" rel="nofollow">Vertes Akos;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of ChemistryThe George Washington UniversityWashington DC 20052 USA;</p> <p>Department of ChemistryThe George Washington UniversityWashington DC 20052 USA;</p> <p>Department of ChemistryThe George Washington UniversityWashington DC 20052 USA;</p> <p>Research Center for Genetic MedicineChildren's National Medical CenterWashington DC 20010 USA;</p> <p>UES Inc.Beavercreek OH 45432 USA;</p> <p>Division of Rheumatology School of Medicine and Health SciencesThe George Washington UniversityWashington DC 20037 USA;</p> <p>Division of Rheumatology School of Medicine and Health SciencesThe George Washington UniversityWashington DC 20037 USA;</p> <p>Chemistry DivisionU.S. Naval Research LaboratoryWashington DC 20375 USA;</p> <p>Department of ChemistryThe George Washington UniversityWashington DC 20052 USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mass spectrometry imaging&option=203" rel="nofollow">mass spectrometry imaging;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=laser desorption ionization&option=203" rel="nofollow">laser desorption ionization;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nanopost array&option=203" rel="nofollow">nanopost array;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=NAPA&option=203" rel="nofollow">NAPA;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=lipids&option=203" rel="nofollow">lipids;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=triglycerides&option=203" rel="nofollow">triglycerides;</a> </p> <div class="translation"> 机译：质谱成像;激光解吸电离;纳米孔阵;纳帕;脂质;甘油三酯; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" 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class="tuijian_auth tuijian_authcolor"> Gregg, H. </a> <span>1996</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基质辅助激光解吸/电离的基础研究，使用飞行时间质谱法识别生物分子</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-chinese-mass-spectrometry-society_thesis/0201226201194.html">基质辅助激光解吸电离质谱用于生物组织的质谱成像应用进展</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张莹&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张莹</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陆豪杰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陆豪杰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨芃原&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨芃原</a> <span> <a href="/journal-cn-8285/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 质谱学报 </a> </span> <span> . 2009</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-academic-journal-abstracts_thesis/020121141716.html">基础医学其他学科：生物组织的基质辅助激光解吸电离质谱成像新进展</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=许彬&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 许彬</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=魏开华&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,魏开华</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张学敏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张学敏</a> <span> <a href="/journal-cn-5250/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国学术期刊文摘 </a> </span> <span> . 2006</span><span>,第019期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_analytical-instrumentation_thesis/0201280095358.html">激光解吸后电离质谱成像技术在生物医学分析中的应用</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陆桥&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陆桥</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=聂武艺&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,聂武艺</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=胡勇军&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,胡勇军</a> <span> <a href="/journal-cn-8218/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 分析仪器 </a> </span> <span> . 2020</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-analytical-chemistry_thesis/0201230467435.html">基质辅助激光解吸电离-傅里叶变换离子回旋共振质谱技术用于食用油中甘油三酯的快速分析</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李卫峰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 李卫峰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨秋霞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨秋霞</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=林泽鹏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,林泽鹏</a> <span> <a href="/journal-cn-10804/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 分析化学 </a> </span> <span> . 2018</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-analytical-chemistry_thesis/0201275811781.html">阿尔茨海默症脑组织基质辅助激光解吸电离质谱成像分析研究新进展</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张阳阳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张阳阳</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=韩超&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,韩超</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵镇文&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,赵镇文</a> <span> <a href="/journal-cn-10804/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 分析化学 </a> </span> <span> . 2019</span><span>,第010期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-27149_thesis/020221768302.html">香豆素衍生物在基质辅助激光解吸/电离飞行时间质谱测定多肽和蛋白质样品中的应用</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邓慧敏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 邓慧敏</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张珍英&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张珍英</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邓芹英&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,邓芹英</a> <span> <a href="/conference-cn-27149/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国质谱学会第七届会员代表大会暨学术报告会 </a> <span> <span> . 2004</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/0203140868.html">基质辅助激光解吸电离质谱扫描生物组织切片成像方法的建立及应用</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=许彬&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 许彬</a> <span> . 2007</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" 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