Effects of Composition,Solvent,and Salt Particles on the Physicochemical Properties of Polyglycolide/Poly(lactide-co-glycolide) Scaffolds

摘要

Polyglycolide (PGA)/poly(lactide-co-glycolide) (PLGA) scaffolds were fabricated by a solvent casting/particulate leaching method using hexafluoroisopropanol (HFIP) or acetone for material dissolution and NaCl particles as porogen.The results revealed that the mechanical strength increased as the PGA percentage in a HFIP-processed scaffold increased.Chemical ingredients did not substantially affect the mechanical strength of acetone-processed scaffolds.Large NaCl particles led to weak mechanical strength,low porosity,and small specific surface area.For a fixed composition,PGA crystals in a HFIP-processed scaffold were smaller than those in an acetone-processed scaffold.High PGA fractions yielded partly fused PGA/PLGA scaffolds.A faster degradation rate of a scaffold could result from a higher PGA percentage,smaller NaCl particles,or the existence of chondrocytes.The combination of PGA and PLGA,which compensated each other for bioactivity,would be beneficial to cartilage regeneration.