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Dendritic polymers for dermal drug delivery

机译:用于真皮药物递送的树突式聚合物

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摘要

Skin-mediated therapeutic delivery is a potential alternative to traditional drug delivery approaches. However, dermal drug delivery is limited to the molecules with optimal physico-chemical properties. To overcome this barrier for delivering 'nonideal' drug molecules across the skin, different drug carriers and penetration enhancement methods have been investigated. Conventional chemical and physical approaches for dermal drug delivery are limited by their skin irritation potential, complexity of application and poor patient compliance. In recent years, dendritic polymers have shown potential in improving the dermal delivery of various molecules. With minimal skin irritation potential and high drug loading capacity, den-drimers offer multiple advantages for improving delivery of drugs across the skin. The current review aims to provide an overview of dendritic polymers for dermal (topical and transdermal) drug delivery.
机译:皮肤介导的治疗递送是传统药物递送方法的潜在替代方案。 然而,真皮药物递送限于具有最佳的物理化学性质的分子。 为了克服在皮肤上递送“非皮肤”药物分子的屏障,已经研究了不同的药物载体和渗透性增强方法。 皮肤输出的常规化学和物理方法受其皮肤刺激潜力,应用复杂性和患者依从性差的限制。 近年来,树枝状聚合物表明了改善各种分子的皮肤递送的可能性。 具有最小的皮肤刺激潜力和高药物负载能力,Den-Drimers提供多种优势,可改善穿过皮肤的药物。 目前的审查旨在概述真皮(局部和透皮)药物递送的树突聚合物。

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