首页> 外文期刊>The Journal of craniofacial surgery >Posterior Vault Distraction Osteogenesis in Nonsyndromic Patients: An Evaluation of Indications and Safety
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Posterior Vault Distraction Osteogenesis in Nonsyndromic Patients: An Evaluation of Indications and Safety

机译:非正式患者的后拱牵引骨质骨质发生:适应症和安全评估

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Purpose:The purpose of this study was to evaluate the indications, safety, and short-term outcomes of posterior vault distraction osteogenesis (PVDO) in patients with no identified acrocephalosyndactyly syndrome (study) and to compare those to a syndromic cohort (controls).Methods:Demographic and perioperative data were recorded and compared across the study and control groups for those who underwent PVDO between January 2009 and December 2016. Univariate analysis was conducted using (2) and Fisher exact tests for categorical variables, and Mann-Whitney U test for continuous variables.Results:Sixty-three subjects were included: 19 in the nonsyndromic cohort, 44 in the syndromic cohort. The cohorts had similar proportion of subjects exhibiting pansynostosis (42.1% of nonsyndromic versus 36.4% of syndromic, P=0.667). The nonsyndromic cohort was significantly older (4.043.66 years versus 2.55 +/- 3.34 years, P=0.046) and had higher rate of signs of raised intracranial pressure (68.4% versus 25.0%, P=0.001) than the syndromic cohort. There was no significant difference in perioperative variables or rate of complications (P0.05). The mean total advancement distance achieved was similar, 27 +/- 6mm in the nonsyndromic versus 28 +/- 8mm in the syndromic cohort (P=0.964). All nonsyndromic subjects with signs of raised intracranial pressure demonstrated improvement at an average follow-up of 22 months.Conclusion:As in the syndromic patient, PVDO is a safe and, in the short-term, effective modality for cranial vault expansion in the nonsyndromic patient. The benefits and favorable perioperative profile of PVDO may therefore be extended to patient populations other than those with syndromic craniosynostosis.
机译:目的:本研究的目的是评估未鉴定的Acrocephalosyndactysys综合征(研究)的患者后拱柱分散型成骨(PVDO)的指示,安全性和短期结果,并将那些与综合征队列(对照)进行比较。方法:记录并在2016年1月至2016年1月至12月之间接受PVDO的研究和对照组进行记录和围手术期数据。使用(2)和Fisher精确测试进行分类变量,以及Mann-Whitney U测试进行单变量分析。对于连续变量。结果:包括六十三个科目:19 in非合成型队列中的19个,综合征队列中的44个。群组具有相似的受试者展示PANSnyososis的比例(42.1%的非合成瘤,患者患者的36.4%,P = 0.667)。非合成瘤队列较大(4.043.66岁,与2.55 +/- 3.34岁,P = 0.046),升高的颅内压力率较高(68.4%对25.0%,p = 0.001),而不是综合征队列。围手术期变量或并发症率没有显着差异(P& 0.05)。所达到的平均总进步距离是相似的,在综合征队列中的非同学与28 +/- 8mm中的27 +/- 6mm(p = 0.964)。所有没有颅内压迹象的非正式受试者,均为22个月的平均随访迹象。结论:如在综合征患者中,PVDO是一个安全的,并且在短期,有效的颅骨穹窿扩张中的颅穹窿扩张。病人。因此,PVDO的益处和良好的围手术期概况可以扩展到除了综合组织颅骨的患者之外的患者群体。

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