Modification of Oligopeptides Increasing the Effectiveness of Their Interaction with Interleukin-8 in Human Blood Plasma

摘要

Molecular modeling, which identified several peptide sequences, was carried out in search for compounds capable of reducing the interleukin-8 concentration in human blood plasma. The replacement of the glutamic acid residue in the Glu-His-OMe and Glu-His-Trp-OMe compounds by its cyclic form, as well as the introduction of the DTyr and DAla residues into the sequence Asp-Tyr-Ala-Pro, was shown to double their ability to bind interleukin-8.