Prenatal Air Pollution and Newborns' Predisposition to Accelerated Biological Aging EDITORIAL COMMENT

摘要

Telomere length (TL) is considered amolecular marker of biological aging. Telomeres shorten with each cellular division, and their length is associated with age-related diseases, lifestyle factors such as smoking, and environmental factors that influence the oxidative stress and inflammatory status in humans. Airborne particulate matter (PM) was ranked as the sixth leading risk factor influencing public health worldwide in 2015 by the Global Burden of Disease Study and is proposed to exert its adverse mechanism on human health through reactive oxygen species and inflammation. Long-term exposure to PMhas been associated with decreased TL in adults. However, little is known about the association between prenatal PM exposure and TL at birth.