Pre-hydration in cisplatin-based CCRT: Effects on tumour concentrations and treatment outcome

摘要

Aims: Pre-hydration is routinely applied to reduce nephrotoxicity in concurrent cisplatin-based chemoradiotherapy (CCRT). However, pre-hydration may also have systemic effects, potentially leading to lower tumour cisplatin concentrations. We investigated the impact of pre-hydration on tumour cisplatin concentrations in mice, and on treatment outcomes in a clinical cohort study.