Rolled-up magnetic sensor: Nanomembrane architecture for in-flow detection of magnetic objects

摘要

Detection and analysis of magnetic nanoobjects is a crucial task in modern diagnostic and therapeutic techniques applied to medicine and biology. Accomplishment of this task calls for the development and implementation of electronic elements directly in fluidic channels, which still remains an open and nontrivial issue. Here, we present a novel concept based on rolled-up nanotechnology for fabrication of multifunctional devices, which can be straightforwardly integrated into existing fluidic architectures. We apply strain engineering to roll-up a functional nanomembrane consisting of a magnetic sensor element based on [Py/Cu]_(30) multilayers, revealing giant magnetoresistance (GMR). The comparison of the sensor's characteristics before and after the roll-up process is found to be similar, allowing for a reliable and predictable method to fabricate high-quality ultracompact GMR devices. The performance of the rolled-up magnetic sensor was optimized to achieve high sensitivity to weak magnetic fields. We demonstrate that the rolled-up tube itself can be efficiently used as a fluidic channel, while the integrated magnetic sensor provides an important functionality to detect and respond to a magnetic field. The performance of the rolled-up magnetic sensor for the in-flow detection of ferromagnetic CrO_2 nanoparticles embedded in a biocompatible polymeric hydrogel shell is highlighted.