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Construction and Manipulation of Functional Three-Dimensional Droplet Networks

机译:功能三维液滴网络的构建与操纵

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摘要

Previously, we reported the manual assembly of lipid-coated aqueous droplets in oil to form two-dimensional (2D) networks in which the droplets are connected through single lipid bilayers. Here we assemble lipid-coated droplets in robust, freestanding 3D geometries: for example, a 14-droplet pyramidal assembly. The networks are designed, and each droplet is placed in a designated position. When protein pores are inserted in the bilayers between specific constituent droplets, electrical and chemical communication pathways are generated. We further describe an improved means to construct 3D droplet networks with defined organizations by the manipulation of aqueous droplets containing encapsulated magnetic beads. The droplets are maneuvered in a magnetic field to form simple construction modules, which are then used to form larger 2D and 3D structures including a 10-droplet pyramid. A methodology to construct freestanding, functional 3D droplet networks is an important step toward the programmed and automated manufacture of synthetic minimal tissues.
机译:以前,我们报道了油中脂质包裹的水滴的手动组装,以形成二维(2D)网络,其中液滴通过单个脂质双层连接。在这里,我们以坚固,独立的3D几何形状组装涂有脂质的液滴:例如14滴金字塔状组件。设计网络,并将每个液滴放置在指定位置。当蛋白质孔插入特定成分小滴之间的双层中时,就会产生电气和化学连通途径。我们进一步描述了一种通过操纵包含封装磁珠的水性液滴来构建具有定义组织的3D液滴网络的改进方法。在磁场中操纵液滴以形成简单的构造模块,然后将其用于形成更大的2D和3D结构,包括10液滴金字塔。构造独立的,功能性3D小滴网络的方法学是朝合成最小组织的程序化和自动化制造迈出的重要一步。

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