Antiplatelet (aspirin) therapy as a new option in the treatment of vasculogenic erectile dysfunction: a prospective randomized double-blind placebo-controlled study

摘要

Abstract Purpose To investigate the efficiency of antiplatelet (aspirin) therapy in vasculogenic erectile dysfunction (VED) patients with a high mean platelet volume. Methods A total of 184 patients diagnosed with VED between the ages of 18 and 76 were randomly divided into two groups and treated for 6?weeks [group 1: 120 patients (mean age 48.3), aspirin 100?mg/day; group 2: 64 patients (mean age 47.7), placebo 100?mg/day]. The changes from baseline to end point in erectile function scores on the International Index of Erectile Function (IIEF-EF) and the number of patients who answered “yes” to questions 2 and 3 of the sexual encounter profile (SEP) were compared statistically. Results The mean baseline IIEF-EF scores in groups 1 and 2 were 14.1?±?4.9 and 14.3?±?5.2, respectively ( p ?=?0.7966), the number of patients who answered “yes” to SEP-2 was 62 (51.6%) in group 1 and 32 (50%) in group 2 ( p ?=?0.8366), and the number of patients who answered “yes” to SEP-3 was 38 (31.6%) in group 1 and 20 (31.2%) in group 2 ( p ?=?0.9557). In the aspirin group, the changes from baseline to end point in the IIEF-EF, SEP-2, and SEP-3 scores were 7.2, 36.6, and 46.6%, respectively. In the placebo group, these changes were 2.0, 9.4, and 12.5%, respectively. When compared with the placebo group, aspirin-treated subjects showed a significant improvement in all three efficacy measures ( p ? Conclusions 100?mg of aspirin administered once a day significantly improved EF in men with VED.