Rnase A Post Mitotic Destabilisation of Nuclear Membrane in Testicular Cells

摘要

RNase A is an endonuclease synthesised in pancreas and maintained inactive by inhibitor until required. So, treatment of testicular cells with RNAse lead to nuclear membrane destabilisation in germ cells through nucleoporin disassembly post mitotically as the synthesis is not affected. RNase A mainly affects the maturation of NPCs as the NPC seed formation is seen and immature NPCs are clearly visible.