Synthesis, characterization and biomolecular interactions of Cu(II) and Ni(II) complexes of acyclic Schiff base ligand

摘要

AbstractMononuclear copper(II) (1) and nickel(II) complexes (2) of acyclic Schiff base ligand,N,N′-bis(2-hydroxy-1-naphthyl)-1,4-bis(3-iminopropyl) piperazine (L) were synthesized and characterized. The molecular structure of the ligand was confirmed using single crystal X-ray diffraction analysis. The complexes displayed good binding abilities to bovine serum albumin protein (BSA). The binding interactions of complexes1and2with calf thymus DNA (CT-DNA) was investigated by absorption, fluorescence, circular dichroism spectral analysis and molecular docking studies. Complex1showed greater interaction with DNA than nickel(II) complex2. The cleavage studies with pBR322 DNA showed efficient oxidative cleavage in the presence of 3-mercaptopropionicacid (MPA) and for hydrogen peroxide for complexes1and2respectively.Graphical abstractDisplay OmittedHighlights?Mononuclear complexes of acyclic Schiff base ligand?Complexes presented good binding propensity to BSA and CT-DNA.?Copper(II) complex having greater DNA interaction than nickel(II) complex.?The complexes showed efficient oxidative cleavage of pBR322 DNA.]]>