Calix-salen cavitand as colorimetric chemosensor for Cu2+ and anticancer activity of copper cavitate

摘要

The calix-salen cavitand is found to bind Cu2+ preferentially among the 1st raw transition metal ions and alkali metal ions. The marked change was observed in the absorption maximum of cavitand on recognition of Cu2+ ion. The binding of copper ion also reflected in the visual colour change from yellow to green. The binding was selective for Cu2+ with little interference from iron. From Job's plot it is found that the cavitand binds copper with 1:1 stoichiometry which is further supported by DFT calculations. We synthesized the copper-cavitate and characterized it by spectroscopic techniques. Cytotoxicity assay using MTT was performed to determine anti proliferative efficacy of copper-cavitate on IMR 32, MCF-7 and L132 cell lines. The copper cavitate is found to be potent antineoplastic agent. The same has been confirmed by gene expression studies.