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Synthesis, structure, antidiabetic and antioxidant properties of a new Co(II) complex with a flexible tripodal ligand

机译:新CO(II)复合物的合成,结构,抗糖尿病和抗氧化性能与柔性三架子配体

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摘要

A novel 3D Co(II) complex {[Co-3(TTTMB)(4)(SCN)(6)]center dot 3.5H(2)O}(n) (1) has been synthesized through the reaction of a flexible tripodal ligand 1,3,5-tris(triazol-1-ylmethyl)- 2,4,6-trimethylbenzene (TTTMB) with Co(NO3)(2) and KSCN. Single crystal X-ray diffraction determination shows that complex 1 crystallizes in the monoclinic space group C2/c and exhibits three crystallographically independent Co(II) ions with the similar coordination environment but different bond lengths and angles. The overall structure of complex 1 can be described as a (3,4)-connected network with the topological notation of (4.8(2))(2)(8(4).12(2))(4(2).8(4))(2). The antidiabetic activity against alpha-amylase and antioxidant activity against 1,1-diphenyl-2-picrylhydrazil (DPPH) of complex 1 are evaluated in vitro. The IC50 values of the complex 1 on alpha-amylase and DPPH are 1.27 mg/mL and 1.53 mg/mL, respectively, which are lower than those of corresponding standard acarbose (2.89 mg/mL) and vitamin E (2.39 mg/mL), indicating that the complex 1 is a new potential antidiabetic and antioxidant drug. Additionally, the solid-state fluorescent properties and thermal stability of the complex are investigated at room temperature.
机译:一种新型的3D CO(II)复合物(II)复合物([CO-3(TTTMB)(4)(4)(4)(4)(6)]中心点3.5H(2)O}(n)(n)(1)已经通过柔性的反应合成了三码头配体1,3,5-三(三唑-1-基甲基) - 2,4,6-三甲基苯(TTTMB),CO(NO3)(2)和KSCN。单晶X射线衍射测定表明,复合物1在单斜晶间空间组C2 / C中结晶,并在具有相似的配位环境,但不同的键长和角度上表现出三个晶体独立的CO(II)离子。复合物1的整体结构可以描述为(3,4)连接网络,其拓扑符号(4.8(2))(2)(8(4).12(2))(4(2)。 8(4))(2)。在体外评估对α-淀粉酶的抗糖尿病酶和抗氧化剂活性对1,1-二苯基-2-纤维酰基(DPPH)的抗氧化活性进行评估。 α-淀粉酶和DPPH上的复合物1的IC 50值分别为1.27mg / ml和1.53mg / ml,低于相应的标准炭疽(2.89mg / ml)和维生素E(2.39mg / ml) ,表明复合物1是新的潜在抗糖尿病和抗氧化药物。另外,在室温下研究了固态的荧光特性和复合物的热稳定性。

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