Bone-targeting poly(ethylene sodium phosphate)

Yasuhiko Iwasaki; Atsushi Yokota; Akihisa Otaka; Naoyuki Inoue; Akane Yamaguchi; Toru Yoshitomi; Keitaro Yoshimoto; Masashi Neo

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Bone-targeting poly(ethylene sodium phosphate)

机译：骨靶向聚（磷酸钠）

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Poly(ethylene sodium phosphate) (PEP路Na) showed excellent cytocompatibility and in vivo bone affinity. Moreover, PEP路Na did not interact with thrombin, which is a coagulation-related protein. Because immobilization of therapeutic agents and imaging probes on PEP路Na is easily performed, PEP路Na is a promising polymer for bone-targeted therapies.

机译：聚（磷酸钠）（PEP路NA）显示出优异的细胞膜相容性和体内骨亲和力。此外，PEP路NA没有与凝血酶相互作用，这是一种与凝固相关的蛋白质。由于容易进行治疗剂和成像探针的固定，PEP路NA是用于骨靶向疗法的有希望的聚合物。

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《Biomaterials Science》 |2018年第1期|共5页
作者
Yasuhiko Iwasaki; Atsushi Yokota; Akihisa Otaka; Naoyuki Inoue; Akane Yamaguchi; Toru Yoshitomi; Keitaro Yoshimoto; Masashi Neo;
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作者单位

Department of Chemistry and Materials Engineering Kansai University 3-3-35 Yamate-cho Suita-shi Osaka 564-8680 Japan;

Department of Orthopedic Surgery Osaka Medical College 2-7 Daigakumachi Takatsuki Osaka 569-8686 Japan;

ORDIST Kansai University 3-3-35 Yamate-cho Suita-shi Osaka 564-8680 Japan;

Department of Chemistry and Materials Engineering Kansai University 3-3-35 Yamate-cho Suita-shi Osaka 564-8680 Japan;

Department of Life Sciences Graduate School of Arts and Sciences The University of Tokyo 3-8-1 Komaba Meguro Tokyo 153-8902 Japan;

Department of Life Sciences Graduate School of Arts and Sciences The University of Tokyo 3-8-1 Komaba Meguro Tokyo 153-8902 Japan;

Department of Life Sciences Graduate School of Arts and Sciences The University of Tokyo 3-8-1 Komaba Meguro Tokyo 153-8902 Japan;

Department of Orthopedic Surgery Osaka Medical College 2-7 Daigakumachi Takatsuki Osaka 569-8686 Japan;

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正文语种 eng
中图分类计量学;
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1. Bone-targeting poly(ethylene sodium phosphate) [J] . Yasuhiko Iwasaki, Atsushi Yokota, Akihisa Otaka, Biomaterials Science . 2018,第1期

机译：骨靶向聚（磷酸钠）
2. Thermally Assisted Generation of Protein–Poly(ethylene sodium phosphate) Conjugates with High Mineral Affinity [J] . Susita Noree, Yasuhiko Iwasaki ACS Omega . 2019,第2期

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3. Endocytosis of poly(ethylene sodium phosphate) by macrophages and the effect of polymer length on cellular uptake [J] . Otaka Akihisa, Iwasaki Yasuhiko Journal of industrial and engineering chemistry . 2019,第期

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4. Cellular interactions and bone affinity of poly(ethylene sodium phosphate) [C] . Yasuhiko Iwasaki, Atsushi Yokota, Akihisa Otaka, Society for Biomaterials annual meeting and exposition . 2018

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Bone-targeting poly(ethylene sodium phosphate)

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