Goal-directed perfusion to reduce acute kidney injury: A randomized trial

摘要

ObjectiveTo determine whether a goal-directed perfusion (GDP) strategy aimed at maintaining oxygen delivery (DO2) at ≥280?mL·min?1·m?2reduces the incidence of acute kidney injury (AKI). MethodsThis multicenter randomized trial enrolled a total of 350 patients undergoing cardiac surgery in 9 institutions. Patients were randomized to receive either GDP or conventional perfusion. A total of 326 patients completed the study?and were analyzed. Patients in the treatment arm were treated with a GDP strategy during cardiopulmonary bypass (CPB) aimed to maintain DO2at ≥280?mL·min?1·m?2. The perfusion strategy for patients in the control arm was factored on body surface area and temperature. The primary endpoint was the rate of AKI. Secondary endpoints were intensive care unit length of stay, major morbidity, red blood cell transfusions, and operative mortality. ResultsAcute Kidney Injury Network (AKIN) stage 1 was reduced in patients treated with GDP (relative risk [RR], 0.45; 95% confidence interval [CI], 0.25-0.83;P?=?.01). AKIN stage 2-3 did not differ between the 2 study arms (RR, 1.66; 95% CI, 0.46-6.0;P?=?.528). There were no significant differences in secondary outcomes. In a prespecified analysis of patients with a CPB time between 1 and 3?hours, the differences in favor of the treatment arm were more pronounced, with an RR for AKI of 0.49 (95% CI, 0.27-0.89;P?=?.017). ConclusionsA GDP strategy is effective in reducing AKIN stage 1 AKI. Further?studies are needed to define perfusion interventions that may reduce more severe levels of renal injury (AKIN stage 2 or 3).