Diketopyrrolopyrrole and benzodithiophene based near infrared-emitting small molecule for imaging applications

摘要

Donor-acceptor semiconductor molecules can be used for imaging applications due to their tunable band gaps and optical properties. In this report, a new donor-acceptor semiconductor small molecule based on diketopyrrolopyrrole and benzodithiophene was synthesized, and it showed emission extended to the near-infrared window. The small molecule was encapsulated into poly(ethylene glycol)-b-poly(epsilon-caprolactone) polymeric micelles through an oil/water emulsion method to provide aqueous solubility. After encapsulation, the absorbance broadened and shifted to a longer wavelength. The micellar system was examined for potential imaging application using A549 lung cancer cells.