Structure activity relationship studies of imidazo(1,2-a)pyrazine derivatives against cancer cell lines.

Myadaraboina S; Alla M; Saddanapu V; Bommena VR; Addlagatta A

首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Structure activity relationship studies of imidazo(1,2-a)pyrazine derivatives against cancer cell lines.

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Structure activity relationship studies of imidazo(1,2-a)pyrazine derivatives against cancer cell lines.

机译：咪唑（1,2-A）吡嗪衍生物对癌细胞系的结构活性关系研究。

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Designed novel imidazo[1,2-a]pyrazine based inhibitors, synthesized by condensing alpha-aminopyrazines with alpha-halocarbonyl compounds followed by electrophilic substitutions. Cytotoxic effects on four cancer cell lines evaluated. Based on preliminary data, imidazo[1,2-a]pyrazine template redesigned to improve activity.

机译：设计的新型咪唑基[1,2-A]吡嗪基抑制剂，通过用α-卤代羰基化合物冷凝α-氨基甲基化合物合成，然后用电电泳取代。评估四种癌细胞系的细胞毒性作用。基于初步数据，咪唑[1,2-A]吡嗪模板重新设计以改善活动。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第11期|共9页
作者
Myadaraboina S; Alla M; Saddanapu V; Bommena VR; Addlagatta A;
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Organic Chemistry Division-II Indian Institute of Chemical Technology Tarnaka-uppal road Tarnaka;

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正文语种 eng
中图分类药学;
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1. Structure activity relationship studies of imidazo(1,2-a)pyrazine derivatives against cancer cell lines. [J] . Myadaraboina S, Alla M, Saddanapu V, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：咪唑并（1,2-a）吡嗪衍生物对癌细胞系的结构活性关系研究。
2. Structure activity relationship studies of imidazo(1,2-a)pyrazine derivatives against cancer cell lines. [J] . Myadaraboina S, Alla M, Saddanapu V, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：咪唑（1,2-A）吡嗪衍生物对癌细胞系的结构活性关系研究。
3. Studies of two different cancer cell lines activities (MDAMB-231 and SK-N-SH) of imidazo[1,2-a]pyrazine derivatives by combining DFT and QSAR results [J] . Samir Chtita, Majdouline Larif, Mounir Ghamali, International Journal of Innovative Research in Science, Engineering and Technology . 2013,第11期

机译：结合DFT和QSAR结果研究咪唑并[1,2-a]吡嗪衍生物的两种不同癌细胞系活性（MDA MB-231和SK-N-SH）
4. Stilbene analogues as inhibitors of breast cancer Stem cells through P-glycoprotein efflux; A 3D quantitative structure-activity relationship study (Inhibitory activity of stilbenes analogues on breast cancer stem cells) [C] . Anushree Tripathi, Krishna Misra 2016 International Conference on Bioinformatics and Systems Biology . 2016

机译：Stilbene类似物通过P-糖蛋白外排作为乳腺癌干细胞的抑制剂； 3D定量结构-活性关系研究（Stilbenes类似物对乳腺癌干细胞的抑制活性）
5. Design and synthesis of novel amide and dithiocarbamate ester analogs of podocarpic acid and the 7-alkyl substituted testosterone derivatives for studies in prostate cancer cell lines. [D] . Mouamba, Claudia. 2010

机译：pod果酸和7-烷基取代的睾丸激素衍生物的新型酰胺和二硫代氨基甲酸酯类似物的设计和合成，用于前列腺癌细胞系的研究。
6. Synthesis Central Nervous System Activity and Structure-Activity Relationships of Novel 1-(1-Alkyl-4-aryl-45-dihydro-1H-imidazo)-3-substituted Urea Derivatives [O] . Elżbieta Szacoń, Marzena Rządkowska, Agnieszka A. Kaczor, 2015

机译：新型1-（1-烷基-4-芳基-45-二氢-1H-咪唑）-3-取代的尿素衍生物的合成中枢神经系统活性和构效关系
7. Synthesis of Novel 2-Butyl-1H-Benzo 4, 5 Imidazo 1, 2-A Imidazo 4, 5-E Pyridine-5-Carbonitrile Derivatives and Evaluation of Their Anticancer Activity [O] . Achanta Venkata Hanumantha Rao, Rayam Parsharamulu, Malthum Shankaraiah, 2016

机译：新型2-丁基-1H-苯并4,5咪唑1,2-A咪唑4,5-e吡啶-5-腈衍生物及其抗癌活性的评价
8. Quantum Mechanical Studies on Chemical Reactivity and Ballistic Chemistry. VI. Literature Review on the Relationship between Structure and Reactivity in Isomeric Tetrazole Derivatives. [R] . Schroeder, M. A. 1975

机译：化学反应性与弹道化学的量子力学研究。 VI。异构四唑衍生物结构与反应性关系的文献综述。

Structure activity relationship studies of imidazo(1,2-a)pyrazine derivatives against cancer cell lines.

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