Exploring the mechanisms for the radical induced damage of 6‐thioguanine

Sandhiya Lakshmanan; Senthilkumar Kittusamy

摘要

Abstract >The oxidation of thioguanine (6‐TG) by reactive radicals such as ?OH, ?OCl, ?OOH, and ?OONO has been studied using density functional theory methods. The radical addition to the C‐atomic sites of 6‐TG occurs more favorably at the C8‐position. The radical addition to the S‐atom of 6‐TG proceeds through the formation of guanine sulfenate radical which is more stable than the peroxo intermediate formed through UVA mediated photooxidation of 6‐TG. Thus, the formation of guanine sulfenate radical resists its full oxidation to guanine sulphonate, a highly effectual blocking agent to replication and transcription. The ring opening and rearrangement of the radical adducts lead to the formation of a spiro compound, more feasibly by the ?OONO attack. The ?OONO is not highly reactive toward radical addition reactions, but induces damage to DNA through the formation of spiro compounds. The attack of the radicals at four sites of 6‐TG, N1, N10, N9, and C8 have been studied and the order of preferred sites for dehydrogenation of 6‐TG by reactive radicals can be quantified as N1??N9??N10??C8. The ?OCl is equally reactive as ?OH in oxidizing 6‐TG. The electron transfer reactions between 6‐TG and the radicals under study are endergonic in both gas and aqueous phases. The present study deals with the important mechanisms involved in the radical induced damage of 6‐TG in competition with the UVA mediated photooxidation of 6‐TG. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type =“main”> <title类型=“main”>抽象</ title> >通过反应自由基（如Δh，ohl，oh和？Oono）的反应自由基氧化（6-Tg）的氧化已经使用密度泛函理论方法研究。在C8位置的6-Tg的C-原子位点的基底除外更有利地发生。 6-TG的S原子的根本除了通过形成通过UVA介导的6-TG的光氧化光氧化而形成的鸟嘌呤硫酸盐自由基。因此，硫氨酸硫酸酯的形成抵抗其对胍磺酸盐的完全氧化，是复制和转录的高度有效的阻塞剂。自由基加合物的环开口和重排导致螺螺旋化合物的形成，更可靠地通过？Oono攻击。 oono对自由基添加反应的反应性并不高度反应，但通过形成螺旋化合物对DNA造成损伤。研究了6-Tg，N1，N10，N9和C8的四个位点的基团的攻击，并且通过反应自由基脱氢的优选位点的顺序可以量化为N1→Δn9？＆？n10？＆？c8。 αOC1同等是反应性的，因为氧化6-Tg oh。在6-Tg和研究中的基团之间的电子转移反应是气体和水相的止回性。本研究涉及在竞争中涉及6-TG竞争中的激进诱导损伤的重要机制，6-Tg的光氧化。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-21753/'>《International Journal of Quantum Chemistry》</a> <b style="margin: 0 2px;">|</b><span>2018年第11期</span><b style="margin: 0 2px;">|</b><span>共13页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sandhiya Lakshmanan&option=202" target="_blank" rel="nofollow">Sandhiya Lakshmanan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Senthilkumar Kittusamy&option=202" target="_blank" rel="nofollow">Senthilkumar Kittusamy;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of PhysicsBharathiar UniversityCoimbatore 641 046 Tamil Nadu India;</p> <p>Department of PhysicsBharathiar UniversityCoimbatore 641 046 Tamil Nadu India;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1186.html" title="物理化学（理论化学）、化学物理学">物理化学（理论化学）、化学物理学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=DNA damage&option=203" rel="nofollow">DNA damage;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=oxidation mechanism&option=203" rel="nofollow">oxidation mechanism;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=reactive oxygen species&option=203" rel="nofollow">reactive oxygen species;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=6‐thioguanine&option=203" rel="nofollow">6‐thioguanine;</a> </p> <div class="translation"> 机译：DNA损伤;氧化机理;活性氧物种;6-硫圆柱; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704019755805.html">Exploring the mechanisms for the radical induced damage of 6‐thioguanine</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sandhiya Lakshmanan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sandhiya Lakshmanan,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Senthilkumar Kittusamy&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Senthilkumar Kittusamy </a> <a href="/journal-foreign-21753/" target="_blank" rel="nofollow" class="tuijian_authcolor">International Journal of Quantum Chemistry .</a> <span>2018</span><span>,第11期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：探索激进诱导的6-Thioguanine损伤的机制</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/070406560045.html">Mechanisms of free radical-induced damage to DNA</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=DizdarogluM.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">DizdarogluM.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=JarugaP.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">JarugaP. </a> <a href="/journal-foreign-24722/" target="_blank" rel="nofollow" class="tuijian_authcolor">Free radical research .</a> <span>2012</span><span>,第4期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：自由基诱导的DNA损伤机理</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/070403220941.html">alpha-Tocopherol induces calnexin in renal tubular cells: Another protective mechanism against free radical-induced cellular damage</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lee WH&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Lee WH,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Akatsuka S&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Akatsuka S,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shirase T&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Shirase T,</a> <a href="/journal-foreign-19505/" target="_blank" rel="nofollow" class="tuijian_authcolor">Archives of Biochemistry and Biophysics .</a> <span>2006</span><span>,第2期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：α-生育酚在肾小管细胞中诱导钙联接蛋白：另一种保护机制，抵抗自由基引起的细胞损伤</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-265358_thesis/0705015200499.html">Damage-inducing mechanism in low-k films due to VUV, UV radiation, radical and ion in etching and ashing plasma</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=K. Takeda&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">K. Takeda,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Y. Miyawaki&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Y. Miyawaki,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=M. Sekine&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">M. Sekine,</a> <a href="/conference-foreign-265358/" target="_blank" rel="nofollow" class="tuijian_authcolor">Advanced Metallization Conference .</a> <span>2010</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：由于VUV，UV辐射，自由基和离子在蚀刻和灰化等离子体中导致的低k薄膜损伤机理</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061708989.html">Gas-phase ion -molecule reactions in mass spectrometric studies of phenyl radical-induced damage on peptides and in the characterization of functional groups in unknown compounds</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li, Sen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Li, Sen </a> <span>2008</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：气相离子分子反应在质谱中研究苯基自由基引起的肽损伤以及未知化合物中官能团的表征</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/0400074314.html">Cytoprotective Mechanisms Mediated by Polyphenols from Chilean Native Berries against Free Radical-Induced Damage on AGS Cells</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Felipe Ávila&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Felipe Ávila,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cristina Theoduloz&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Cristina Theoduloz,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Camilo López-Alarcón&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Camilo López-Alarcón,</a> <span>2017</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：智利本土浆果多酚介导的抗AGS细胞自由基诱导的细胞保护机制</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000124081323.html">α-Tocopherol induces calnexin in renal tubular cells: Another protective mechanism against free radical-induced cellular damage</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wen-Hua Lee&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wen-Hua Lee,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shinya Akatsuka&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Shinya Akatsuka,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tomoyuki Shirase&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Tomoyuki Shirase,</a> <span>2006</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：α-生育酚在肾小管细胞中诱导萼素：另一个免受自由基诱导的细胞损伤的保护机制</span> </p> </li> <li> <div> <b>8. </b><a class="enjiyixqcontent" href="/ntis-science-report_ad_thesis/02071963603.html">Mechanisms of Chemically Induced Brain Damage. Are Free Radicals a CommonEffector Linkage</a> <b>[R] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pazdernik, T. L.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Pazdernik, T. L. </a> <span>1996</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：化学诱导脑损伤的机制。自由基是一个共同效应者联系</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_modernization-traditional-chinese-medicine-materia-medica-world-science-technology_thesis/0201221589617.html">大黄素诱导自噬改善顺铂导致肾小管细胞损伤机制探索</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘红&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘红</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=孙伟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,孙伟</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=顾刘宝&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,顾刘宝</a> <span> <a href="/journal-cn-5736/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界科学技术-中医药现代化 </a> </span> <span> . 2017</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_china-journal-modern-medicine_thesis/0201288804900.html">七氟醚诱导肝损伤大鼠模型microRNA-214的表达变化及其损伤机制探讨</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=马杰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 马杰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张琛&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张琛</a> <span> <a href="/journal-cn-6691/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国现代医学杂志 </a> </span> <span> . 2021</span><span>,第007期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_medical-information_thesis/0201252427724.html">间歇性缺氧诱导胰岛β细胞损伤及其损伤机制</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=孙丽华&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 孙丽华</a> <span> <a href="/journal-cn-6677/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 医学信息 </a> </span> <span> . 2014</span><span>,第024期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-analytical-chemistry_thesis/0201271884016.html">基于Aβ25-35诱导的PC12细胞损伤模型研究定志小丸治疗阿尔兹海默病的作用机制及配伍机制</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郑妍&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 郑妍</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘舒&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘舒</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=宋凤瑞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,宋凤瑞</a> <span> <a href="/journal-cn-10804/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 分析化学 </a> </span> <span> . 2018</span><span>,第011期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-animal-veterinary-sciences_thesis/0201261025009.html">H5N1亚型禽流感病毒感染番鸭引起肺损伤和脑损伤的机制探索</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李奇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 李奇</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=叶昱&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,叶昱</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=佟铁铸&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,佟铁铸</a> <span> <a href="/journal-cn-7126/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 畜牧兽医学报 </a> </span> <span> . 2016</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-5760_thesis/020221444673.html">游离脂肪酸诱导心肌细胞损伤的新机制探索</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陆立慧&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陆立慧</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵明月&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,赵明月</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李君丽&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李君丽</a> <span> <a href="/conference-cn-5760/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2013中国生理学会心血管生理学术会议 </a> <span> <span> . 2013</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020314940868.html">高分子量透明质酸治疗LPS诱导的急性肺损伤的活性研究及初步机制探索</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈小明&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈小明</a> <span> . 2017</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120112106979.html">BMSC-Exo对高糖诱导HK2细胞损伤保护机制的研究方法</a> <b>[P]</b> . <span> 中国专利： CN112111459A </span> <span> . 2020-12-22</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120215386786.html">一种探索降雨诱发滑坡机制的现场试验装置</a> <b>[P]</b> . <span> 中国专利： CN215577101U </span> <span> . 2022-01-18</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130432835776.html">a compound or a pharmaceutically acceptable salt thereof, method for treating or inhibiting disease, methods for lowering cholesterol, triglycerides, lp (a), or ldl; or inhibit vascular wall damage to provide increased cognition or neuroprotection; to treat or inhibit free radical-induced disease states, conditions, and joint swelling or erosion; or treat or inhibit joint damage secondary to arthroscopic or surgical procedures, and, pharmaceutical composition</a> <b>[P]</b> . <span> 外国专利：  BRPI0514628A </span> <span> . 2008-06-17</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：化合物或其药学上可接受的盐，治疗或抑制疾病的方法，降低胆固醇，甘油三酸酯，lp（a）或ldl的方法;或抑制血管壁损伤以增强认知或神经保护;治疗或抑制自由基引起的疾病，状况以及关节肿胀或糜烂;或治疗或抑制由于关节镜或外科手术而引起的关节损伤，以及药物组合物 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130409928203.html">METHODS AND COMPOSITIONS FOR TREATMENT OF DISORDERS ASSOCIATED WITH DAMAGE INDUCED BY FREE RADICALS</a> <b>[P]</b> . <span> 外国专利：  US2017157010A1 </span> <span> . 2017-06-08</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：治疗自由基引起的疾病的方法和组合物 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130412439812.html">Controlled release compositions for modulating free-radical induced damage and methods of use thereof</a> <b>[P]</b> . <span> 外国专利：  US9427472B2 </span> <span> . 2016-08-30</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于调节自由基引起的损伤的控释组合物及其使用方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704019755805','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)" title="意见反馈">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);" title="回到顶部">回到顶部</a> </li> <li class="shouye"> <a href="/" title="首页">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html" title="关于掌桥">关于掌桥</a></li> <li><a href="/help/helpmap.html" title="资源导航">资源导航</a></li> <li><a href="/help/helpguide.html" title="新手指南">新手指南</a></li> <li><a href="/help/helpcenter.html" title="常见问题">常见问题</a></li> <li><a href="/sitemap.html" title="网站地图">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9" title="版权声明">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank" title="ICP备案号">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704019755805down" data-source="7," data-out-id="R2yiEq4N3MT+PAlNhhWi0FALo4rBYYEB2YdZng3DbPAxzMAibUCV1Rx5KCb9YYZy," data-f-source-id="7" data-title="Exploring the mechanisms for the radical induced damage of 6‐thioguanine" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="21753" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Exploring the mechanisms for the radical induced damage of 6‐thioguanine"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/newmail.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.8"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/sse.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.8"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>