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A new magnetic resonance imaging contrast agent loaded into poly(lacide-co-glycolide) nanoparticles for long-term detection of tumors

机译:一种新型的磁共振成像造影剂,可加载到聚(丙交酯-共-乙交酯)纳米颗粒中,用于长期检测肿瘤

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摘要

The incorporation of a lipophilic Gd chelate (GdDO3A-C_(12)) in biocompatible PLGA poly(D, Llactide- co-glycolide) nanoparticles was explored as an approach to increase the relaxivity of contrast agents for magnetic resonance imaging. By nanoprecipitation, it was possible to obtain PEGylated gadolinium nanoparticles (mean diameter of 155 nm) with high Gd loading (1.1 × 10~4 Gd centers per nanoparticle). The corresponding GdDO3AC_(12)?NPs nanoparticles exhibited an enhanced relaxivity (up to sixfold greater than DOTAREM? at 40 MHz) because the nanoparticle framework constrained the lipophilic Gd chelate motion and favorably impacted the Gd chelate rotational correlation time. T_1-weighted imaging at 3 T on phantoms showed enhanced contrast for the GdDO3AC_(12)?NPs. Importantly, Gd chelate leakage was almost nonexistent, which suggested that these GdDO3AC_(12)? NPs could be useful for long-term MRI detection.
机译:探索了将亲脂性Gd螯合物(GdDO3A-C_(12))掺入生物相容的PLGA聚(D,丙交酯-共-乙交酯)纳米颗粒中作为增加造影剂磁共振成像弛豫性的方法。通过纳米沉淀,可以获得高Gd负载(每个纳米颗粒1.1×10〜4 Gd中心)的PEG化g纳米颗粒(平均直径155 nm)。相应的GdDO3AC_(12)?NPs纳米粒子表现出增强的弛豫性(在40 MHz时比DOTAREM?高出六倍),因为纳米粒子框架限制了亲脂性Gd螯合物的运动并有利地影响了Gd螯合物的旋转相关时间。幻影上3 T处的T_1加权成像显示GdDO3AC_(12)?NPs的对比度增强。重要的是,Gd螯合物泄漏几乎不存在,这表明这些GdDO3AC_(12)? NP可用于长期MRI检测。

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