Reply to comment on 'Therapeutic application of metallic nanoparticles combined with particle-induced x-ray emission effect'

摘要

Upon receiving a comment (Le Sech etal 2012 Nanotechnology 23 078001) on the mechanism in therapeutic effects of proton-irradiation on a tumor model given metallic nanoparticles (MNP), potential dose enhancements due to particle induced radiation (PIR) from MNP including x-ray and Auger electrons were explained, and newly termed as particle induced radiation therapy (PIRT). All other biological or chemical modulation including enhanced ROS due to PIR are also subject to further investigation. In addition, new works in this field since our original paper (Kim etal 2010 Nanotechnology 21 425102) was published were briefly introduced.