For research on inhomogeneous cells, we present a simulation method called the dual-medium quantitative (DMQ) measurement simulation method, which is realized by combining phase-shifting digital holography with DMQ analysis. The reliability of this method is confirmed by comparing the simulated phase map with the experimental one by the Hilbert phase microscope [J. Phys. Chem. A 113, 13327 (2009)], and its ability for studying inhomogeneous cells is demonstrated with measurements of a simulated HeLa cell. The average deviation and the relative deviation of physical thickness and axially averaged refractive index are 0.0339 (mu)m, 0.69percent and 0.0013, 0.094percent, respectively. This approach can provide good guidance for experimental research on inhomogeneous cells.
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