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Total variation regularization for nonlinear fluorescence tomography with an augmented Lagrangian splitting approach

机译:用增强拉格朗日分裂方法进行非线性荧光层析成像的总变化正则化

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摘要

Fluorescence tomography is an imaging modality that seeks to reconstruct the distribution of fluorescent dyes inside a highly scattering sample from light measurements on the boundary. Using common inversion methods with L~(2) penalties typically leads to smooth reconstructions, which degrades the obtainable resolution. The use of total variation (TV) regularization for the inverse model is investigated. To solve the inverse problem efficiently, an augmented Lagrange method is utilized that allows separating the Gauss-Newton minimization from the TV minimization. Results on noisy simulation data provide evidence that the reconstructed inclusions are much better localized and that their half-width measure decreases by at least 25percent compared to ordinary L~(2) reconstructions.
机译:荧光层析成像是一种成像方法,旨在根据边界上的光测量结果来重建高散射样品内荧光染料的分布。使用具有L〜(2)罚分的常用反演方法通常会导致平滑重构,从而降低可获得的分辨率。研究了总变化(TV)正则化在逆模型中的使用。为了有效地解决反问题,利用了增强的拉格朗日方法,该方法允许将高斯-牛顿最小化与电视最小化分开。嘈杂的模拟数据的结果提供了证据,表明与普通的L〜(2)重建相比,重建后的夹杂物具有更好的局部性,并且其半角宽度测量值至少降低了25%。

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