Glass ampoules were always sealed by melting in the presence of a flame to create closures. Some poisonous gases were generated in this sealing process that pollute the injection drug and are physically harmful. In this study, CO_(2) lasers were proposed for sealing glass ampoules. Because of the clean non-contact sealing process with lasers, there was nearly no pollution of the injection drug. To study in detail the principle of this sealing process, a mathematical model was put forward, and the temperature and the thermal stress field around the ampoule's neck were calculated by ANSYS software. Through experimental study, 1 ml and 5 ml ampoules were sealed successfully by a dual-laser-beam method. The results show that a laser source is an ideal heat source for sealing glass ampoules.
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