Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three-Component Synthesis of Functionalized -Ketoamides

摘要

Using a flow microreactor system, carbamoyllithium compounds were successfully generated and used for reactions with electrophiles to give various amides, including -ketoamides. The present method could be applied to the three-component synthesis of functionalized -ketoamides using a carbamoyllithium compound, methyl chloroformate, and a functionalized organolithium reagent.