Cooperative Lewis Acid/Cp*Co-III Catalyzed C-H Bond Activation for the Synthesis of Isoquinolin-3-ones

摘要

A facile route toward the synthesis of isoquinolin-3-ones through a cooperative B(C6F5)(3)- and Cp*Co-III-catalyzed C-H bond activation of imines with diazo compounds is presented. The inclusion of a catalytic amount of B(C6F5)(3) results in a highly efficient reaction, thus enabling unstable NH imines to serve as substrates.