F-18-Labeling of Aryl-SCF3, -OCF3 and -OCHF2 with [F-18]Fluoride

摘要

We report that halogenophilic silver(I) triflate permits halogen exchange (halex) nucleophilic F-18-fluorination of aryl-OCHFCl, -OCF2Br and -SCF2Br precursors under mild conditions. This Ag-I-mediated process allows for the first time access to a range of F-18-labeled aryl-OCHF2, -OCF3 and -SCF3 derivatives, inclusive of [F-18]riluzole. The F-18-labeling of these medicinally important motifs expands the radiochemical space available for PET applications.