Cobalt(II)-Catalyzed C-sp2-H Alkynylation/ Annulation with Terminal Alkynes: Selective Access to 3-Methyleneisoindolin-1-one

摘要

A highly efficient cobalt(II)-catalyzed alkynylation/annulation of terminal alkynes assisted by an N, O-bidentate directing group is described. This protocol is characterized by wide substrate scope utilizing cheap cobalt catalysts, and offers a new approach to 3-methyleneisoindolin-1-one, which can be converted into an oxadiazine salt in one step. Moreover, the directing group could be removed in three steps.