AgF-Mediated Fluorinative Cross-Coupling of Two Olefins: Facile Access to alpha-CF3 Alkenes and beta-CF3 Ketones

摘要

A AgF-mediated fluorination with a concomitant cross-coupling between a gem-difluoroolefin and a non-fluorinated olefin is reported. This highly efficient method provides facile access to both -CF3 alkenes and -CF3 ketones, which otherwise remain challenging to be directly prepared. The application of this method is further demonstrated by the synthesis of bioactive isoxazoline derivatives. This approach represents a conceptually novel route to trifluoromethylated compounds that combines the insitu generation of the CF3 moiety and a CH functionalization in a single reaction system.