Asymmetric Dual-Reagent Catalysis: Mannich-type Reactions Catalyzed by Ion Pair

摘要

The combination of a new bifunctional phosphine and an acrylate generate a zwitterion insitu and it serves as an efficient catalyst for asymmetric reactions through a homogeneous ion-pairing mode. This new catalytic system has been successfully applied to Mannich-type reactions to give excellent results and it demonstrates a broad substrate scope. Such reactivity is not accessible with general organophosphine catalytic modes. Preliminary investigations into the mechanism are also presented.