Single-Flask Multicomponent Palladium-Catalyzed alpha,gamma-Coupling of Ketone Enolates: Facile Preparation of Complex Carbon Scaffolds

摘要

A three-component palladium-catalyzed reaction sequence has been developed in which gamma-substituted alpha,beta-unsaturated products are obtained in a single flask by an alpha-alkenylation with either a subsequent gamma-alkenylation or gamma-arylation of a ketone enolate. Coupling of a variety of electronically and structurally different components was achieved in the presence of a Pd/Q-Phos catalyst (2 mol%), usually at 22 degrees C with yields of up to 85%. Most importantly, access to these products is obtained in one simple operation in place of employing multiple reactions.